The most common side effects of Ciprofloxacin are nausea, vomiting, stomach pain, and diarrhea. These side effects usually go away on their own within a few days and usually resolve on their own within a week or two.
If your doctor has directed you to stop Ciprofloxacin, there are a few things you can do to ease the symptoms of your infection:
It is not possible to determine if your infection is viral or bacterial, nor can it be determined with certainty whether your infection is caused by Ciprofloxacin or if you are more likely to be a viral or bacterial infection. You should not breastfeed while you are taking Ciprofloxacin.
If you are a resident of a rural area, you are more likely to be at risk of getting an infection if you live in a remote area and are also taking the following medications:
If you are a woman, Ciprofloxacin may affect your menstrual period (amenorrhoea) and possibly affect your ovulation (egg quality) or cause vaginal bleeding. In some women, Ciprofloxacin may cause vaginal irritation, which can be treated with a topical or oral contraceptive cream or oral antifungal treatment.
If you are taking other medications, talk to your doctor before starting Ciprofloxacin to rule out any contraindications.
You can stop taking Ciprofloxacin and tell your doctor if you continue to experience any of the following symptoms:
If you are pregnant or planning to become pregnant, talk to your doctor before taking Ciprofloxacin.
Ciprofloxacin is not recommended for use in children under 16 years of age except for medical reasons.
Ciprofloxacin may cause a condition known as azotemia.
If you are at risk of getting an infection, talk to your doctor about ways to help.
Read moreYou can take Ciprofloxacin with or without food. However, taking Ciprofloxacin with food may help reduce the symptoms of an infection. If you have diarrhea or other symptoms of an infection, talk to your doctor right away.
Ciprofloxacin may not work for everyone. You may not be able to take Ciprofloxacin or you may not be able to take it and your immune system may not function. You should talk to your doctor about ways to treat your condition with Ciprofloxacin.
Ciprofloxacin may affect your menstrual period (amenorrhoea) and may cause vaginal bleeding. If you have any of the following symptoms of an infection, talk to your doctor right away about trying an alternative antibiotic:
Ciprofloxacin can affect your fertility and may affect your sex life.
Ciprofloxacin passes into breast milk. If you are breastfeeding, your doctor will probably not want to use Ciprofloxacin because you may not be able to breastfeed while taking it.
Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.
May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.
Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.
Vomiting, Stomach pain, Nausea, Diarrhea
Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.
Store between 20-25°C.
Quinolones
Use for urinary tract infections, lower respiratory tract infections, prostatitis, prophylaxis against otitis media, sinusitis, skin and soft tissue infections, bone and joint infections, scalp infections, gastrointestinal infections, tonsillitis ( faecal-sores), sinusitis, skin and bone infections.Reduces the likelihood of receiving a dose of ciprofloxacin-susceptible ophthalmic lesion. Caution necessary for oedema and inflammation in eyes. May be used with other quinolones. May be used with other quinolones in patients with acute bacterial sinusitis and tonsillitis. May be used with other quinolones in patients with chronic bacterial sinusitis and tonsillitis.
Hypersensitivity to quinolones. Cisapride or other similar imidazoles have been used in post-menopausal women to decrease symptoms and to treat symptoms following coronary or cerebrovascular accident. Use with caution in patients with lung disease. Caution is advised in patients with hepatic impairment. Renal and renal dysfunction. Interactions with other medications: gliclazide, nitroprusside, thioridazine.
May be mild, moderate or severe.\
Common side effects: vomiting, diarrhea, nausea, hepatotoxicity, neuromuscular disorders, seizures, oedema, edema.Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.
May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.
Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.
Vomiting, Stomach pain, Nausea, Diarrhea
Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.
Store between 20-25°C.
Quinolones
Use only as directedDihydrofolic acid, quinone reductase inhibitor, quinolone antibiotic
MedsGo Class: Class C; Use only as directedUse only as directed, and in special circumstances, and in special diet (SSD) as advised by your healthcare provider. Manufactured by India Chemicals & Fishery Pvt. Ltd.
alking erect with wind. Finishes in both adults and children 8 years of age and older. The colour of the initial material is orange. The colour may vary depending on the manufacturer. Finishes may be slightly different from the other colours. The remaining colours may vary depending on the manufacturer. The final material, initial material, and later material are similar. The final material is slightly different. The colour of the final material may vary. The colour may be more peeling, a slightly different texture, or slightly more hyamy.
Do not use more or less than the suggested dose. Keep out of sight and reach of children. Keep out of reach of children. Store in its original container. Store away from heat, moisture, and light. Do not store in the bathroom. Remove any cap or twist seal. Wash your hands before applying this remedy. Remove any loose bandage. Rinse the affected area with water after applying this remedy. Do not apply to eyes. Rinse the affected area with plenty of water. Do not apply to skin. Rinse the affected area with plenty of warm water. Apply to skin in particular. Apply to skin in the following areas: under upper lip, around upper arms, around neck, sides, back, neck, and upper back. Apply to skin in the following areas: upper chest, around neck, sides, back, neck, sides, lower chest, around shoulders, under arms, upper thighs, and under arms. Apply to skin in the following areas: under lower chest, around shoulders, under lower chest, under lower arms, under lower thighs, under lower thighs, under lower arms, under lower thighs, and under lower buttocks.
The aim of this work is to investigate the pharmacological effect of tetracyclines on the metabolism of ciprofloxacin hydrochloride (CIPC) and their potential impact on the ciprofloxacin hydrochloride (CIPH) concentration in the serum of human volunteers. An interaction was observed between the two drugs in the presence of CIPC, and the CIPH concentration was measured using a UV spectrophotometer in the presence of CIPC at 25 °C and 25 °C. At the 25 °C and 25 °C, the maximum values of the fluoroquinolones (CIPC and CIPH) concentration were 3.5 and 2.9 μM, respectively. At 25 °C, the ciprofloxacin concentration was 7.4 and 3.8 μM, respectively. The mean concentrations of CIPC and CIPH in the serum of the volunteers were lower than that in the plasma. The CIPH concentration decreased by 2.8 and 4.2 μM, respectively. The CIPC concentrations in the serum of the volunteers were lower than those in plasma. Ciprofloxacin and CIPH were metabolized in different steps, and the results suggest that the CIPC concentration in the serum of the volunteers is lower than that in the plasma. The results of this study were consistent with the results obtained by other authors that the CIPC concentration in the serum of volunteers is higher than that in plasma. The mechanism by which CIPC concentrations are affected by the pharmacological effect of tetracyclines is not well understood. This is in line with the results obtained by other authors that the CIPC concentration in the serum of volunteers is lower than that in plasma, which may be due to the different modes of metabolism of the two drugs. It is possible that the pharmacological effect of tetracyclines may be mediated by different pathways and/or that the pharmacological effect of CIPC and CIPH may be mediated by different pathways. This is in line with the results obtained by other authors that the CIPC concentration in the serum of volunteers is higher than that in the plasma.
Citation:Bosch A, De Geuwerth B, Schuetze S, Heydt S, Böttli B, et al. (2021) Aquifex-Based Effect of Tetracyclines on Ciprofloxacin Hydrochloride in Human Subjects. PLoS ONE 16(5): e0222929. https://doi.org/10.1371/journal.pone.0222929
Editor:Wendy H. A. H. Böttli, University of Pennsylvania School of Medicine, United States of America
Received:November 13, 2021;Accepted:May 25, 2022;Published:June 12, 2022
Copyright:© 2021 Bosch et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:This work was supported by a grant from the Swedish Research Council (SAF-2015-639, Grant Number: 2017-2329), and the Swedish Research Council (2014-63-3048, Grant Number: 2016-06498). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Antibiotic-resistance genes and mechanisms play a significant role in the evolution of bacteria and the evolution of microbes. The resistance of bacteria to antibiotic treatments increases when the bacteria have developed resistance mechanisms, such as antibiotic efflux pumps, which regulate bacterial metabolism. Resistance to antibiotics can be acquired in microbes by a wide variety of factors, including genetic modification, genetic mutations and other mechanisms such as drug efflux pumps and antibiotic efflux pumps [, ].
The ciprofloxacin hydrochloride (CIPC) is one of the most commonly used antibiotics in the world [, ].
Stade de France Pharmacy