Ciprofloxacin HCL (Ciprofloxacin/Trimethoprim/Disulfiram) is a broad-spectrum antibiotic belonging to the fluoroquinolone class, including ciprofloxacin. Ciprofloxacin is effective against a wide range of bacterial infections, including but not limited to urinary tract infections, respiratory tract infections, skin and soft tissue infections, and bone and joint infections. Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes responsible for DNA replication and repair. It is effective against certain types of bacterial infections caused by gram-negative and gram-positive bacteria, such as:

• Clostridium difficile
• Escherichia coli
• Klebsiella pneumoniae
• Proteus mirabilis
• Proteus vulgaris
• Staphylococcus aureus

The drug Ciprofloxacin is classified as a fluoroquinolone that is effective against a wide range of gram-positive and gram-negative bacteria, such as

• Bacteroides species
• Enterococcus
• Pseudomonas aeruginosa
• Klebsiella species

In the case of gram-positive and gram-negative bacteria, Ciprofloxacin is effective against bacteria that have already been established through a culture and sensitivity test. However, bacteria that have already been shown to be susceptible to Ciprofloxacin, are typically resistant to the drug. In this article, we discuss the potential drug interactions of Ciprofloxacin in the treatment of UTIs, respiratory tract infections, and bone and joint infections.

Ciprofloxacin Hydrochloride (Ciprofloxacin HCl)

Ciprofloxacin hydrochloride is a broad-spectrum antibiotic that is effective against a wide range of bacterial infections, including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and other bacterial infections. Ciprofloxacin hydrochloride is used to treat infections caused by susceptible bacteria in the urinary tract, including those caused by,, and. Ciprofloxacin hydrochloride is also effective in treating conditions such as:

• Skin and soft tissue infections
• Bone and joint infections

This drug is commonly used to treat urinary tract infections caused by susceptible bacteria. It is also effective against some types of infections, such as urinary tract infections, which are often associated with infections caused by susceptible bacteria, and skin and soft tissue infections, which are caused by non- susceptible bacteria.

Ciprofloxacin hydrochloride is available as an oral suspension, which may be taken by mouth.

Side Effects of Ciprofloxacin (Ciprofloxacin HCl)

Ciprofloxacin hydrochloride (Ciprofloxacin/Trimethoprim/Disulfiram) is a potent antibiotic that is effective against a broad spectrum of bacterial infections, including urinary tract infections, respiratory tract infections, skin and soft tissue infections, and bone and joint infections.

This article was updated on 1 June 2020.

Generic Name & Form of the DrugGeneric Name (AND )

Brand Name(s):	Ciprofloxacin/Sulphate

Ciprofloxacin/Sulphate Eye Drops

The generic name for Ciprofloxacin/Sulphate is, the active ingredient in.

Ciprofloxacin/Sulphate is an antibiotic and antiprotozoal agent used to treat a wide variety of bacterial infections, including ear infections, skin infections, and respiratory infections. It works by killing bacteria that are unable to multiply within the body and that cause infections. The drug belongs to a class of medications known as quinolones, which work by stopping the growth of bacteria.

Uses of The Ciprofloxacin/Sulphate Eye Drops

• Treatment of bacterial infections in patients who are susceptible to ciprofloxacin.
• Treatment of ear infections and other ear conditions caused by susceptible bacteria.
• Treatment of skin infections caused by susceptible organisms.

Dosage The maximum dose for Ciprofloxacin/Sulphate is 100 milligrams (mg) per kg (2.5 mg/kg) body weight. For the treatment of infections in the ears, a single dose of ciprofloxacin/sulphate is given twice daily for seven days. For the treatment of infections in the skin, a single dose of ciprofloxacin/sulphate is given twice daily for 14 days. For the treatment of infections in the eyes, a single dose of ciprofloxacin/sulphate is given twice daily for 14 days. For the treatment of ear infections, a single dose of ciprofloxacin/sulphate is given twice daily for 14 days. For the treatment of ear infections caused by susceptible bacteria, a single dose of ciprofloxacin/sulphate is given twice daily for 14 days. The dosage for eye infections is 100 mg/dose per day.

Use The Ciprofloxacin/Sulphate Eye Drops

• Eye infections caused by susceptible bacteria.
• Ear infections caused by susceptible organisms.

Side Effects The generic name of Ciprofloxacin/Sulphate is Flovent (ciprofloxacin).

• The most common side effects are diarrhea, dizziness, headache, nausea, vomiting, and rash.
• More severe side effects may include, a painful or prolonged erection lasting for more than 4 hours, chest pain, vision problems, and,,, and allergic reactions.

Drug Interactions There are no drug interactions reported for Ciprofloxacin/Sulphate.

Drug Warnings The generic name of Ciprofloxacin/Sulphate is Flovent. It is important to note that Ciprofloxacin/Sulphate should not be used in patients who are also taking another anti-inflammatory agent. Patients taking other anti-inflammatory agents, including acetaminophen, aspirin, or similar drugs should avoid taking Ciprofloxacin/Sulphate, as it can increase the risk of side effects. Patients with liver disease or a history of liver disease should also avoid taking Ciprofloxacin/Sulphate. Ciprofloxacin/Sulphate should only be used with a doctor’s prescription, as it can cause side effects in some patients. Therefore, Ciprofloxacin/Sulphate should only be used with a doctor’s prescription.

The Food and Drug Administration on Thursday warned consumers not to use the drug Ciprofloxacin for more than a year and a half than the previous FDA warning label suggests.

The warning label was written in May 2010, and it's been updated twice by FDA, once by an independent panel of scientists and then the agency's own agency, the Federal Drug Administration, in February 2011.

The agency's advisory panel recommended that Cipro-200 and Cipro-600 be used for less than a year and a half, and that Ciprofloxacin be taken for the longer term.

"We think that the warning label should have been added to the package insert," Dr. Robert B. Gerhard, director of the FDA's Center for Drug Evaluation and Research, told ABC News. "The FDA has no data showing that Ciprofloxacin for longer than a year and a half, or more than 30 days, or more than 30 days, or more than 1 year, could be used to treat serious bacterial infections."

The warning label was revised by the FDA in June 2011, and the agency has said its safety and efficacy have been assessed to determine whether the drug could be used as a preventative treatment for bacterial infections.

"The FDA is in the process of evaluating the safety and efficacy of Ciprofloxacin, a broad-spectrum antibiotic, and its approved indication for this drug is to treat bacterial infections of the ear, nose, throat, urinary tract, skin, and soft tissue," it said.

The FDA has yet to comment on whether the drug is being used as a preventive treatment for ear, nose, throat, urinary tract infections, and other similar conditions.

The label also stated that a "risk" for serious side effects was not reported.

In a statement, the FDA said: "These labels have been updated to ensure that Ciprofloxacin is used in accordance with the FDA's guidance on the safety of the drug and to ensure that the drug is used appropriately and effectively."

In response, Pfizer said the agency's safety and efficacy have been assessed to determine whether Ciprofloxacin is an appropriate treatment for serious bacterial infections.

It also said it has not conducted any studies to determine whether the drug is effective in treating bacterial infections, and that it has not been shown to have any known side effects.

In June 2010, the FDA issued a warning label, saying it did not recommend Ciprofloxacin for more than a year and a half.

On Wednesday, the FDA released a letter from Pfizer saying it is "reviewing and evaluating the safety and efficacy of Ciprofloxacin for the treatment of serious bacterial infections and to assess whether it has the potential to be used as an effective preventive treatment for these infections."

The FDA's letter said Pfizer is reviewing the safety and efficacy of Ciprofloxacin for the treatment of serious bacterial infections and is "reviewing and evaluating the potential for Ciprofloxacin to be used as a preventative treatment for these infections."

On Thursday, the agency will update the agency's safety and efficacy panel with a new warning label.

"Pfizer is committed to the safety and efficacy of this drug and is committed to a balanced approach to care, including the development of safer alternatives for patients with complex illnesses, and a responsible approach to the treatment of serious diseases, with a strong commitment to patient safety and to the highest ethical standards," the agency said.

Pfizer's letter also said the FDA is reviewing the safety and efficacy of Ciprofloxacin for the treatment of bacterial infections.

Pfizer said it has not been able to comment on whether the drug is being used as a preventative treatment for bacterial infections.

The FDA said it was reviewing the safety and efficacy of the drug and is "reviewing and evaluating the potential for Ciprofloxacin to be used as a preventative treatment for serious bacterial infections."

For more information about the FDA's latest warning label or for more about the drug, call ABC News at (504) 553-6332.

Cipro 500 Tablets offer powerful immune support for individuals dealing with various conditions.

• Reservedly used for individuals with chronic conditions like chronic obstructive pulmonary disease (COPD) or chronic fatigue syndrome (CFS).
• Helps reduce inflammation and improve lung function.

Save time by managing your symptoms with these trusted tablets.

• Cipro 500 is designed to provide consistent relief for conditions such as:
• Pulmonary Arterial Hypertension (PAH)
• Bronchospasm Relief
• Long-lasting relief of acute symptoms like cough, shortness of breath, and changes in pulse.
• Acute Pulmonary Edema (a condition in which your body becomes inflamed with symptoms such as swelling, rapid breathing, and fluid retention)
• Chronic Fatigue Syndrome (CFS)
• Sedation

Take Cipro 500 as prescribed, up to a maximum daily dose of 500 mg.

How to Use

Use the tablets exactly as prescribed by your doctor. Take them as your body tells you to. Do not skip doses or stop taking the tablets on your own. Your doctor will determine the appropriate dose based on your condition and response to treatment.

Inform your doctor of any other medications you are taking. Cipro 500 may interact with certain vitamins, herbal products, or antacids. This includes antacids (e.g., St. John's wort), iron supplements, or zinc.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take 2 doses at once.

Ingredients

Each tablet contains:

• 500 mg of Ciprofloxacin base

To make the Cipro 500 Tablets, follow these steps:

1. Gently pour the first dose into the small tube that the dosing syringe comes from. This way, the dose can be easily supplied.
2. Slowly pour the second dose into the tube that the dosing syringe comes from.
3. When you are ready to give the tablets, remove the dosing syringe from your hand. Shake well before giving the first dose.
4. Lie down by spreading the affected areas evenly on the surface of the skin. You may need to cover the area with a gauze barrier after each application.
5. Rub gently into the affected area.
6. Do not apply too much or too little of the tablets to the affected area.

If you are applying the tablets to your skin, rinse thoroughly with water. Carefully measure the dose using the dosing syringe provided.

Warnings

Do not use the tablets if:

• You are allergic to ciprofloxacin or any of the ingredients listed at the end of this leaflet.
• You have a heart problem.
• You are pregnant, or you are breast-feeding.
• You are taking aspirin or other NSAID medications.
• You are currently using a CYP3A4 Inhibitor (e.g., imatinib).
• You have a history of gastrointestinal problems, such as stomach ulcers or bleeding problems.

Talk to your doctor or pharmacist before using the tablets if:

• You have kidney problems.
• You have asthma.
• You are a woman.
• You are trying to conceive a child.
• You have systemic lupus erythematosus (SLE), which is a medical condition in which your immune system attacks your joints and other tissues.
• You have an infection of the pancreas, which is caused by bacteria.
• You are currently taking a medicine called indapamide, a medicine used to treat high blood pressure.

Storage

Store the tablets at a temperature below 25 degrees Celsius. Protect from light and moisture. Do not use the tablets if the packaging is damaged or the source of the medication is damaged.

Keep your tablets in the original container and out of the reach of children.